Treatment of patients with severe COVID-19, is challenging specifically when\na patient carries high risk of mortality, such as old age, immune suppression\nor cancer. Also a patient who manifests the disease with severe symptoms,\nsuch as hypoxia, requiring supplemental oxygenation, or artificial ventilation\nhas a poor prognosis. Here we review the scientific rationale used to design a\nvery promising therapy based on existing literature, but in significantly different\nmethod and protocols, used to treat cases of severe COVID-19, and we\nconclude that although the effort on drug development has been enormous,\nbut as of today, we do not have a therapy with specific characteristics as this\nprotocol, to be used safely in human and yet potentially meet the expectations\nwe would have for a so called â??effective therapyâ?. Further clinical trials are\nneeded to support this hypothesis and generate further hypothesis to prove\nthe concept in larger cohort of patients.
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